Protective Effects of Biscoclaurine Alkaloids on Leukopenia Induced by ⁶⁰Co-γ Radiation.

ABSTRACT:

Objective

Leukopenia, a common complication of tumor chemoradiotherapy, contributes serious damage to the hematopoietic, gastrointestinal, and immune systems of the body and can cause delay, discontinuation, or even failure to tumor treatment, thereby greatly threatening human health. The present study aims to investigate the protective effects of biscoclaurine alkaloids (BA) on leukopenia.

Methods

This study was conducted on 60 Kunming mice, which were randomly divided into six groups containing 10 animals each. A hematology analyzer was used to count white blood cells (WBC) in the peripheral blood cell. Mice serum was collected, and the granulocyte-macrophage colony-stimulating factor, vascular cell adhesion molecule 1 (VCAM-1), and interferon-γ (IFN-γ) were

SUBMITTER: Wang M 

PROVIDER: S-EPMC7251465 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature