Better stress coping associated with lower tau in amyloid-positive cognitively unimpaired older adults.

ABSTRACT:

Objective

Research in animals has shown that chronic stress exacerbates tau pathology. In humans, psychological stress has been associated with higher risk of Alzheimer disease clinical syndrome. The objective of this cross-sectional study was to assess the hypothesis that stress coping ability (assessed via the Brief Resilience Scale [BRS]) is associated with tau burden and to evaluate whether these associations differed by sex and amyloid status (A+/A-) in cognitively unimpaired (CU) older adults.

Methods

We included 225 CU participants (mean age 70.4 ± 10.2 years, 48% female) enrolled in the population-based Mayo Clinic Study of Aging who completed the BRS and underwent amyloid-PET (Pittsburgh compound B-PET) and tau-PET (AV1451-PET). We fitted multiple regression and ana

SUBMITTER: Arenaza-Urquijo EM 

PROVIDER: S-EPMC7251516 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature