Modeling disease trajectory in Duchenne muscular dystrophy.

ABSTRACT:

Objective

To quantify disease progression in individuals with Duchenne muscular dystrophy (DMD) using magnetic resonance biomarkers of leg muscles.

Methods

MRI and magnetic resonance spectroscopy (MRS) biomarkers were acquired from 104 participants with DMD and 51 healthy controls using a prospective observational study design with patients with DMD followed up yearly for up to 6 years. Fat fractions (FFs) in vastus lateralis and soleus muscles were determined with ¹H MRS. MRI quantitative T₂ (qT₂) values were measured for 3 muscles of the upper leg and 5 muscles of the lower leg. Longitudinal changes in biomarkers were modeled with a cumulative distribution function using a nonlinear mixed-effects approach.

Results

MRS FF and MRI qT

SUBMITTER: Rooney WD 

PROVIDER: S-EPMC7251517 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature