Identification of amygdala-expressed genes associated with autism spectrum disorder.

ABSTRACT:

Background

Studies of individuals with autism spectrum disorder (ASD) have revealed a strong multigenic basis with the identification of hundreds of ASD susceptibility genes. ASD is characterized by social deficits and a range of other phenotypes, implicating complex genetics and involvement of a variety of brain regions. However, how mutations and mis-expression of select gene sets are associated with the behavioral components of ASD remains unknown. We reasoned that for genes to be associated with ASD core behaviors they must be: (1) expressed in brain regions relevant to ASD social behaviors and (2) expressed during the ASD susceptible window of brain development.

Methods

Focusing on the amygdala, a brain region whose dysfunction has been highly implicated in the social c

SUBMITTER: Herrero MJ 

PROVIDER: S-EPMC7251751 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature