VL30 retrotransposition is associated with induced EMT, CSC generation and tumorigenesis in HC11 mouse mammary stem‑like epithelial cells.

ABSTRACT: Retrotransposons copy their sequences via an RNA intermediate, followed by reverse transcription into cDNA and random insertion, into a new genomic locus. New retrotransposon copies may lead to cell transformation and/or tumorigenesis through insertional mutagenesis. Methylation is a major defense mechanism against retrotransposon RNA expression and retrotransposition in differentiated cells, whereas stem cells are relatively hypo‑methylated. Epithelial‑to‑mesenchymal transition (EMT), which transforms normal epithelial cells into mesenchymal‑like cells, also contributes to tumor progression and tumor metastasis. Cancer stem cells (CSCs), a fraction of undifferentiated tumor‑initiating cancer cells, are reciprocally related to EMT. In the present study, the outcome of long terminal repeat

SUBMITTER: Thrasyvoulou S 

PROVIDER: S-EPMC7251778 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature