Serum free thiols predict cardiovascular events and all-cause mortality in the general population: a prospective cohort study.

ABSTRACT:

Background

Serum free thiols (R-SH, sulfhydryl groups) reliably reflect systemic oxidative stress. Since serum free thiols are rapidly oxidized by reactive species, systemic oxidative stress is generally associated with reduced serum free thiol levels. Free thiols associate with favorable disease outcomes in many patient cohorts, and the current hypothesis is that oxidative stress might also play an important role in cardiovascular disease. In this study, we aimed to establish the role of serum free thiols in the general population by investigating their relationship with the risk of cardiovascular (CV) events and all-cause mortality.

Methods

Participants (n = 5955) of the Prevention of REnal and Vascular ENd-stage Disease (PREVEND) cohort study from the general population w

SUBMITTER: Abdulle AE 

PROVIDER: S-EPMC7251849 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature