The impact of body mass index on adaptive immune cells in the human bone marrow.

ABSTRACT:

Background

Obesity has been associated with chronic inflammation and oxidative stress. Both conditions play a determinant role in the pathogenesis of age-related diseases, such as immunosenescence. Adipose tissue can modulate the function of the immune system with the secretion of molecules influencing the phenotype of immune cells. The importance of the bone marrow (BM) in the maintenance of antigen-experienced adaptive immune cells has been documented in mice. Recently, some groups have investigated the survival of effector/memory T cells in the human BM. Despite this, whether high body mass index (BMI) may affect immune cells in the BM and the production of molecules supporting the maintenance of these cells it is unknown.

Methods

Using flow cytometry, the frequency and t

SUBMITTER: Pangrazzi L 

PROVIDER: S-EPMC7251898 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature