CAMKK2-CAMK4 signaling regulates transferrin trafficking, turnover, and iron homeostasis.

ABSTRACT:

Background

Circulatory iron is a hazardous biometal. Therefore, iron is transported in a redox-safe state by a serum glycoprotein - transferrin (TF). Different organs acquire iron from the systemic circulation through a tightly regulated mechanism at the blood-tissue interface which involves receptor-mediated internalization of TF. Thus, abnormal TF trafficking may lead to iron dyshomeostasis associated with several diseases including neurodegeneration. Iron -induced toxicity can cause neuronal damage to iron-sensitive brain regions. Recently, it was discovered that CAMKK2, a calcium (Ca²⁺)/calmodulin-activated kinase, controls receptor-mediated TF trafficking in mouse tissues, specifically in the brain. The biological function of CAMKK2 is mediated through multiple down

SUBMITTER: Sabbir MG 

PROVIDER: S-EPMC7251913 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature