The Expression of Cancer-Related Genes in Aging Mouse Liver is RXRα and Gender Dependent.

ABSTRACT:

Background

Previous reports have demonstrated that gene expression profiles are modified in several tissue types including liver during the aging process and that such alterations might impact on the development and advancement of certain diseases. To understand the affect of aging on liver cancer, we have studied the expression pattern of cancer-related genes in aging mouse livers. Retinoid x receptor α (RXRα) is a transcription factor that is highly expressed in the liver. RXRα-regulated pathways are implicated in liver detoxification and carcinogenesis. In addition, liver cancer incidence is higher in males than in females. Thus, we have also studied the effects of hepatic RXRα and gender on regulating those cancer-related genes in aging mouse livers.

Results

Hepatic canc

SUBMITTER: Guo M 

PROVIDER: S-EPMC7251938 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature