Dataset Information

In Vivo Disintegration and Bioresorption of a Nacre-Inspired Graphene-Silk Film Caused by the Foreign-Body Reaction.

ABSTRACT: Graphene-based substrates are emerging as a promising functional platform for biomedical applications. Although dispersible graphene sheets have been demonstrated to be biodegradable, their assembled macroscopic architectures are biopersistent because of strong π-π interactions. In this study, we developed a nacre-inspired graphene-silk nanocomposite film by vacuum filtration with a subsequent green chemical reduction procedure. The "brick-and-mortar" architecture not only ensures the mechanical and electrical properties of the film but also endows it with disintegrable and bioresorbable properties following rat subcutaneous implantation. Furthermore, covalent cross-linking leads to the formation of graphene with decreased interlayer spacing, which effectively prolongs the residence time in vivo. We found that enzymatic treatment created microcracks on the film surface and that the foreign-body reaction was involved in the deformation, delamination, disintegration, and phagocytosis processes of the nanocomposite films. This bioinspired strategy paves the way for the development of high-performance graphene-based macroscopic biomaterials with tunable bioresorbability.

SUBMITTER: Li L

PROVIDER: S-EPMC7251954 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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In Vivo Disintegration and Bioresorption of a Nacre-Inspired Graphene-Silk Film Caused by the Foreign-Body Reaction.

Li Linhao L Liang Yanbing Y Wang Guohang G Xu Peng P Yang Lingbing L Hou Sen S Zhou Jin J Wang Lizhen L Li Xiaoming X Yang Li L Fan Yubo Y

iScience 20200513 6

Graphene-based substrates are emerging as a promising functional platform for biomedical applications. Although dispersible graphene sheets have been demonstrated to be biodegradable, their assembled macroscopic architectures are biopersistent because of strong π-π interactions. In this study, we developed a nacre-inspired graphene-silk nanocomposite film by vacuum filtration with a subsequent green chemical reduction procedure. The "brick-and-mortar" architecture not only ensures the mechanical ...[more]

PMID: 32450519

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Project description:Nacre, a natural nanocomposite with a brick-and-mortar structure existing in the inner layer of mollusk shells, has been shown to optimize strength and toughness along the laminae (in-plane) direction. However, such natural materials more often experience impact load in the direction perpendicular to the layers (i.e., out-of-plane direction) from predators. The dynamic responses and deformation mechanisms of layered structures under impact load in the out-of-plane direction have been much less analyzed. This study investigates the dynamic mechanical behaviors of nacre-inspired layered nanocomposite films using a model system that comprises alternating multi-layer graphene (MLG) and polymethyl methacrylate (PMMA) phases. With a validated coarse-grained molecular dynamics simulation approach, we systematically study the mechanical properties and impact resistance of the MLG-PMMA nanocomposite films with different internal nanostructures, which are characterized by the layer thickness and number of repetitions while keeping the total volume constant. We find that as the layer thickness decreases, the effective modulus of the polymer phase confined by the adjacent MLG phases increases. Using ballistic impact simulations to explore the dynamic responses of nanocomposite films in the out-of-plane direction, we find that the impact resistance and dynamic failure mechanisms of the films depend on the internal nanostructures. Specifically, when each layer is relatively thick, the nanocomposite is more prone to spalling-like failure induced by compressive stress waves from the projectile impact. Whereas, when there are more repetitions, and each layer becomes relatively thin, a high-velocity projectile sequentially penetrates the nanocomposite film. In the low projectile velocity regime, the film develops crazing-like deformation zones in PMMA phases. We also show that the position of the soft PMMA phase relative to the stiff graphene sheets plays a significant role in the ballistic impact performance of the investigated films. Our study provides insights into the effect of nanostructures on the dynamic mechanical behaviors of layered nanocomposites, which can lead to effective design strategies for impact-resistant films.

Dataset Information

In Vivo Disintegration and Bioresorption of a Nacre-Inspired Graphene-Silk Film Caused by the Foreign-Body Reaction.

Publications

In Vivo Disintegration and Bioresorption of a Nacre-Inspired Graphene-Silk Film Caused by the Foreign-Body Reaction.

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