Emerging trends in COVID-19 treatment: learning from inflammatory conditions associated with cellular therapies.

ABSTRACT: Coronavirus disease 2019 (SARS-CoV2) is an active global health threat for which treatments are desperately being sought. Even though most people infected experience mild to moderate respiratory symptoms and recover with supportive care, certain vulnerable hosts develop severe clinical deterioration. While several drugs are currently being investigated in clinical trials, there are currently no approved treatments or vaccines for COVID-19 and hence there is an unmet need to explore additional therapeutic options. At least three inflammatory disorders or syndromes associated with immune dysfunction have been described in the context of cellular therapy. Specifically, Cytokine Release Syndrome (CRS), Immune Reconstitution Inflammatory Syndrome (IRIS), and Secondary Hemophagocytic Lymphohisti

SUBMITTER: Cancio M 

PROVIDER: S-EPMC7252029 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature