Expandable human cardiovascular progenitors from stem cells for regenerating mouse heart after myocardial infarction.

ABSTRACT:

Aims

Cardiovascular diseases caused by loss of functional cardiomyocytes (CMs) are a major cause of mortality and morbidity worldwide due in part to the low regenerative capacity of the adult human heart. Human pluripotent stem cell (hPSC)-derived cardiovascular progenitor cells (CPCs) are a potential cell source for cardiac repair. The aim of this study was to examine the impact of extensive remuscularization and coincident revascularization on cardiac remodelling and function in a mouse model of myocardial infarction (MI) by transplanting doxycycline (DOX)-inducible (Tet-On-MYC) hPSC-derived CPCs in vivo and inducing proliferation and cardiovascular differentiation in a drug-regulated manner.

Methods and results

CPCs were injected firstly at a non-cardiac site in Matrigel

SUBMITTER: Schwach V 

PROVIDER: S-EPMC7252440 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature