Platelets are critical for survival and tissue integrity during murine pulmonary Aspergillus fumigatus infection.

ABSTRACT: Beyond their canonical roles in hemostasis and thrombosis, platelets function in the innate immune response by interacting directly with pathogens and by regulating the recruitment and activation of immune effector cells. Thrombocytopenia often coincides with neutropenia in patients with hematologic malignancies and in allogeneic hematopoietic cell transplant recipients, patient groups at high risk for invasive fungal infections. While neutropenia is well established as a major clinical risk factor for invasive fungal infections, the role of platelets in host defense against human fungal pathogens remains understudied. Here, we examined the role of platelets in murine Aspergillus fumigatus infection using two complementary approaches to induce thrombocytopenia without concurrent neutropeni

SUBMITTER: Tischler BY 

PROVIDER: S-EPMC7252636 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature