Global chemical effects of the microbiome include new bile-acid conjugations.

ABSTRACT: A mosaic of cross-phylum chemical interactions occurs between all metazoans and their microbiomes. A number of molecular families that are known to be produced by the microbiome have a marked effect on the balance between health and disease^1-9. Considering the diversity of the human microbiome (which numbers over 40,000 operational taxonomic units¹⁰), the effect of the microbiome on the chemistry of an entire animal remains underexplored. Here we use mass spectrometry informatics and data visualization approaches^11-13 to provide an assessment of the effects of the microbiome on the chemistry of an entire mammal by comparing metabolomics data from germ-free and specific-pathogen-free mice. We found that the microbiota affects the chemistry of all organs. Thi

SUBMITTER: Quinn RA 

PROVIDER: S-EPMC7252668 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature