The early proximal αβ TCR signalosome specifies thymic selection outcome through a quantitative protein interaction network.

ABSTRACT: During αβ T cell development, T cell antigen receptor (TCR) engagement transduces biochemical signals through a protein-protein interaction (PPI) network that dictates dichotomous cell fate decisions. It remains unclear how signal specificity is communicated, instructing either positive selection to advance cell differentiation or death by negative selection. Early signal discrimination might occur by PPI signatures differing qualitatively (customized, unique PPI combinations for each signal), quantitatively (graded amounts of a single PPI series), or kinetically (speed of PPI pathway progression). Using a novel PPI network analysis, we found that early TCR-proximal signals distinguishing positive from negative selection appeared to be primarily quantitative in nature. Furthermore, the sig

SUBMITTER: Neier SC 

PROVIDER: S-EPMC7252671 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature