NKTR-214 immunotherapy synergizes with radiotherapy to stimulate systemic CD8⁺ T cell responses capable of curing multi-focal cancer.

ABSTRACT:

Background

High-dose radiotherapy (RT) is known to be immunogenic, but is rarely capable of driving clinically relevant abscopal antitumor immunity as monotherapy. RT is known to increase antigen presentation, type I/II interferon responses, and immune cell trafficking to irradiated tumors. Bempegaldesleukin (NKTR-214) is a CD122-preferential interleukin 2 (IL-2) pathway agonist that has been shown to increase tumor-infiltrating lymphocytes, T cell clonality, and increase PD-1 expression. NKTR-214 has increased drug half-life, decreased toxicity, and increased CD8⁺ T cell and natural killer cell stimulation compared with IL-2.

Methods

Animals bearing bilateral subcutaneous MCA-205 fibrosarcoma or CT26 colorectal tumors were treated with NKTR-214, RT, or combinatio

SUBMITTER: Walker JM 

PROVIDER: S-EPMC7252958 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature