Efficacy of maternal B₁₂ supplementation in vegetarian women for improving infant neurodevelopment: protocol for the MATCOBIND multicentre, double-blind, randomised controlled trial.

ABSTRACT:

Introduction

Vitamin B₁₂ deficiency is widely prevalent across many low- and middle-income countries, especially where the diet is low in animal sources. While many observational studies show associations between B₁₂ deficiency in pregnancy and infant cognitive function (including memory, language and motor skills), evidence from clinical trials is sparse and inconclusive.

Methods and analysis

This double-blind, multicentre, randomised controlled trial will enrol 720 vegetarian pregnant women in their first trimester from antenatal clinics at two hospitals (one in India and one in Nepal). Eligible mothers who give written consent will be randomised to receive either 250 mcg methylcobalamin or 50 mcg (quasi control), from enrolment to 6 months post-partu

SUBMITTER: Nagpal J 

PROVIDER: S-EPMC7252986 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature