Lifespan of long-lived growth hormone receptor knockout mice was not normalized by housing at 30°C since weaning.

ABSTRACT: Growth hormone receptor knockout (GHRKO) mice are remarkably long-lived and have improved glucose homeostasis along with altered energy metabolism which manifests through decreased respiratory quotient (RQ) and increased oxygen consumption (VO₂ ). Short-term exposure of these animals to increased environmental temperature (eT) at 30°C can normalize their VO₂ and RQ. We hypothesized that increased heat loss in the diminutive GHRKO mice housed at 23°C and the consequent metabolic adjustments to meet the increased energy demand for thermogenesis may promote extension of longevity, and preventing these adjustments by chronic exposure to increased eT will reduce or eliminate their longevity advantage. To test these hypotheses, GHRKO mice were housed at increased eT (30°C)

SUBMITTER: Fang Y 

PROVIDER: S-EPMC7253058 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature