Cortical bone maturation in mice requires SOCS3 suppression of gp130/STAT3 signalling in osteocytes.

ABSTRACT: Bone strength is determined by its dense cortical shell, generated by unknown mechanisms. Here we use the Dmp1^Cre:Socs3^f/f mouse, with delayed cortical bone consolidation, to characterise cortical maturation and identify control signals. We show that cortical maturation requires a reduction in cortical porosity, and a transition from low to high density bone, which continues even after cortical shape is established. Both processes were delayed in Dmp1^Cre:Socs3^f/f mice. SOCS3 (suppressor of cytokine signalling 3) inhibits signalling by leptin, G-CSF, and IL-6 family cytokines (gp130). In Dmp1^Cre:Socs3^f/f bone, STAT3 phosphorylation was prolonged in response to gp130-signalling cytokines, but not G-CSF or

SUBMITTER: Walker EC 

PROVIDER: S-EPMC7253175 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature