ALGINATE versus NPWT in the Preparation of Surgical Excisions for an STSG: ATEC Trial.

ABSTRACT: A calcium alginate dressing (ALGINATE) and negative pressure wound therapy (NPWT) are frequently used to treat wounds which heal by secondary intention. This trial compared the healing efficacy and safety of these 2 treatments.

Methods

This randomized, non-inferiority trial enrolled patients who underwent skin excision (>30 cm²), which was left open to heal by secondary intention. They received ALGINATE or NPWT by a centralized randomization. Follow-up was performed weekly until optimal granulation tissue was obtained. The primary outcome was time to obtain optimal granulation tissue for a split thickness skin graft take (non-inferiority margin: 4 days). Secondary outcomes were occurrence of adverse events (AEs) and impact of the treatments on the patient's daily life.

SUBMITTER: Casanova D 

PROVIDER: S-EPMC7253249 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature