Fatigue in multiple sclerosis is associated with multimodal interoceptive abnormalities.

ABSTRACT:

Background

Fatigue ranks among the most common and disabling symptoms in multiple sclerosis (MS). Recent theoretical works have surmised that this trait might be related to alterations across interoceptive mechanisms. However, this hypothesis has not been empirically evaluated.

Objectives

To determine whether fatigue in MS patients is associated with specific behavioral, structural, and functional disruptions of the interoceptive domain.

Methods

Fatigue levels were established via the Modified Fatigue Impact Scale. Interoception was evaluated through a robust measure indexed by the heartbeat detection task. Structural and functional connectivity properties of key interoceptive hubs were tested by magnetic resonance imaging (MRI) and resting-state functional MRI. Machi

SUBMITTER: Gonzalez Campo C 

PROVIDER: S-EPMC7253315 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature