Contribution of extracellular matrix components to the stiffness of skeletal muscle contractures in patients with cerebral palsy.

ABSTRACT: Purpose: Joint contractures in children with cerebral palsy contain muscle tissue that is mechanically stiffer with higher collagen content than typically developing children. Interestingly, the correlation between collagen content and stiffness is weak. To date, no data are available on collagen types or other extracellular matrix proteins in these muscles, nor any information regarding their function. Thus, our purpose was to measure specific extracellular protein composition in cerebral palsy and typically developing human muscles along with structural aspects of extracellular matrix architecture to determine the extent to which these explain mechanical properties. Materials and Methods: Biopsies were collected from children with cerebral palsy undergoing muscle lengthenin

SUBMITTER: Smith LR 

PROVIDER: S-EPMC7253322 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature