Design and preclinical evaluation of nanostars for the passive pretargeting of tumor tissue.

ABSTRACT:

Introduction

Pretargeting strategies that do not rely on the expression of molecular targets have expanded imaging and therapy options for cancer patients. Nanostars with designed multivalency and which highly accumulate in tumor tissue via the enhanced permeability and retention (EPR) effect may therefore be the ideal vectors for the development of a passive pretargeting approach.

Methods

Nanostars were synthesized, consisting of 7-8 center-cross-linked arms that were modified with trans-cyclooctene (TCO) using poly(ethylene glycol) (PEG) linkers of 12 or 106 monomer units or without linker. The bioorthogonal click reaction with radiofluorinated 2,2'-(7-(2-(tetrazine-poly(ethyleneglycol)₁₁-amino)-2-oxoethyl)-1,4,7-triazonane-1,4-diyl)diacetic acid ([¹⁸

SUBMITTER: Goos JACM 

PROVIDER: S-EPMC7253331 | biostudies-literature | 2020 May - Jun

REPOSITORIES: biostudies-literature