Fluorine-18 labeled poly (ADP-ribose) polymerase1 inhibitor as a potential alternative to 2-deoxy-2-[¹⁸F]fluoro-d-glucose positron emission tomography in oral cancer imaging.

ABSTRACT:

Objectives

The evaluation of disease extent and post-therapy surveillance of head and neck cancer using 2-deoxy-2-[¹⁸F]fluoro-d-glucose ([¹⁸F]FDG) PET is often complicated by physiological uptake in normal tissues of the head and neck region, especially after surgery or radiotherapy. However, irrespective of low positive predictive values, [¹⁸F]FDG PET remains the standard of care to stage the disease and monitor recurrences. Here, we report the preclinical use of a targeted poly (ADP-ribose) polymerase1 (PARP1) binding PET tracer, fluorine-18 labeled poly (ADP-ribose) polymerase1 inhibitor ([¹⁸F]PARPi), as a potential alternative with greater specificity.

Methods

Using an orthotopic xenograft mouse model injected with either FaDu

SUBMITTER: Demetrio de Souza Franca P 

PROVIDER: S-EPMC7253343 | biostudies-literature | 2020 May - Jun

REPOSITORIES: biostudies-literature