Mucosal Microbiota and Metabolome along the Intestinal Tract Reveal a Location-Specific Relationship.

ABSTRACT: The intestinal microbiota is highly metabolically active and plays an important role in many metabolic processes absent from the human host. Altered microbiota metabolism has been linked to diseases such as obesity, cardiovascular disease, and colorectal cancer. However, there is a gap in the current knowledge on how the microbiota interact with its host in terms of metabolic interactions. Here, we performed an integrated analysis between the mucosa-associated microbiota and the mucosa metabolome in healthy, nonhuman primates to investigate these relationships. The microbiota composition was distinct at each tissue location, with variation by host individual also observed. Microbiota-metabolome dynamics were primarily driven by interactions in the distal colon. These interactions were stro

SUBMITTER: Yuan C 

PROVIDER: S-EPMC7253361 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature