Activation of adenosine A₃ receptor protects retinal ganglion cells from degeneration induced by ocular hypertension.

ABSTRACT: Glaucoma is a progressive chronic retinal degenerative disease and a leading cause of global irreversible blindness. This disease is characterized by optic nerve damage and retinal ganglion cell (RGC) death. The current treatments available target the lowering of intraocular pressure (IOP), the main risk factor for disease onset and development. However, in some patients, vision loss progresses despite successful IOP control, indicating that new and effective treatments are needed, such as those targeting the neuroprotection of RGCs. Adenosine A₃ receptor (A₃R) activation confers protection to RGCs following an excitotoxic stimulus. In this work, we investigated whether the activation of A₃R could also afford protection to RGCs in the laser-induced ocular h

SUBMITTER: Boia R 

PROVIDER: S-EPMC7253479 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature