MiR-142-3p Regulates BDNF Expression in Activated Rodent Microglia Through Its Target CAMK2A.

ABSTRACT: Microglia, the innate immune effector cells of the mammalian central nervous system (CNS), are involved in the development, homeostasis, and pathology of CNS. Microglia become activated in response to various insults and injuries and protect the CNS by phagocytosing the invading pathogens, dead neurons, and other cellular debris. Recent studies have demonstrated that the epigenetic mechanisms ensure the coordinated regulation of genes involved in microglial activation. In this study, we performed a microRNA (miRNA) microarray in activated primary microglia derived from rat pup's brain and identified differentially expressed miRNAs targeting key genes involved in cell survival, apoptosis, and inflammatory responses. Interestingly, miR-142-3p, one of the highly up-regulated miRNAs in microgl

SUBMITTER: Gupta N 

PROVIDER: S-EPMC7253665 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature