Characterization of Burkholderia cepacia Complex Core Genome and the Underlying Recombination and Positive Selection.

ABSTRACT: Recombination and positive selection are two key factors that play a vital role in pathogenic microorganisms' population adaptation and diversification. The Burkholderia cepacia complex (Bcc) represents bacterial species with high similarity, which can cause severe infections among cases suffering from the chronic granulomatous disorder and cystic fibrosis (CF). At present, no genome-wide study has been carried out focusing on investigating the core genome of Bcc associated with the two evolutionary forces. The general characteristics of the core genome of Bcc species remain scarce as well. In this study, we explored the core orthologous genes of 116 Bcc strains using comparative genomic analysis and studied the two adaptive evolutionary forces: recombination and positive selection.

SUBMITTER: Zhou J 

PROVIDER: S-EPMC7253759 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature