Association between interleukin-10-819T/C polymorphism and risk of ischemic stroke: A meta-analysis.

ABSTRACT: BACKGROUND:The interleukin-10 (IL-10)-819T/C polymorphism has been indicated to be correlated with ischemic stroke susceptibility, but this relationship remains controversial. A meta-analysis was conducted to investigate the potential association between IL-10-819T/C polymorphism and ischemic stroke risk. METHODS:Databases including Pubmed, Embase, and CNKI were searched. Data were extracted and odds ratios (OR) with 95% confidence intervals (CI) were calculated. RESULTS:Eight case-control studies with 1832 cases and 1520 controls were included in this meta-analysis. IL-10-819T/C polymorphism may decrease the risk of ischemic stroke (C vs T: OR = 1.01, 95% CI: 0.91-1.12; CC vs TT: OR = 0.91, 95% CI: 0.73-1.14; CT vs TT: OR = 1.10, 95% CI: 0.95-1.28; CC + CT vs TT: OR = 1.06, 95% CI: 0.92-1

SUBMITTER: Zuo S 

PROVIDER: S-EPMC7253870 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature