Diminished Reactive Hematopoiesis and Cardiac Inflammation in a Mouse Model of Recurrent Myocardial Infarction.

ABSTRACT:

Background

Recurrent myocardial infarction (MI) is common in patients with coronary artery disease and is associated with high mortality. Long-term reprogramming of myeloid progenitors occurs in response to inflammatory stimuli and alters the organism's response to secondary inflammatory challenges.

Objectives

This study examined the effect of recurrent MI on bone marrow response and cardiac inflammation.

Methods

The investigators developed a surgical mouse model in which 2 subsequent MIs affected different left ventricular regions in the same mouse. Recurrent MI was induced by ligating the left circumflex artery followed by the left anterior descending coronary artery branch. The study characterized the resulting ischemia by whole-heart fluorescent coronary angiograp

SUBMITTER: Cremer S 

PROVIDER: S-EPMC7254576 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature