Effect of baseline cognitive impairment on association between predicted propofol effect site concentration and Bispectral index or sedation score.

ABSTRACT:

Background

This study determined whether the relationship between predicted propofol effect site concentration (Ce) and observer's assessment of alertness/sedation scale (OAA/S) or Bispectral Index (BIS) was similar comparing cognitively intact vs impaired patients undergoing hip fracture repair with spinal anesthesia and sedation.

Methods

Following informed consent baseline mini-mental status exam (MMSE), Clinical Dementia Rating (CDR) and geriatric depression scale (GDS) were obtained. Intraoperatively OAA/S, BIS, and propofol (timing and exact amounts) administered were recorded. Cerebrospinal fluid was collected for Alzheimer's (AD) biomarkers. Mean Ce level (AvgCe) during surgery was calculated using the area under the Ce measurement series from incision to closure, div

SUBMITTER: Sieber F 

PROVIDER: S-EPMC7254641 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature