APOE ε4 genotype-dependent cerebrospinal fluid proteomic signatures in Alzheimer's disease.

ABSTRACT:

Background

Aggregation of amyloid β into plaques in the brain is one of the earliest pathological events in Alzheimer's disease (AD). The exact pathophysiology leading to dementia is still uncertain, but the apolipoprotein E (APOE) ε4 genotype plays a major role. We aimed to identify the molecular pathways associated with amyloid β aggregation using cerebrospinal fluid (CSF) proteomics and to study the potential modifying effects of APOE ε4 genotype.

Methods

We tested 243 proteins and protein fragments in CSF comparing 193 subjects with AD across the cognitive spectrum (65% APOE ε4 carriers, average age 75 ± 7 years) against 60 controls with normal CSF amyloid β, normal cognition, and no APOE ε4 allele (average age 75 ± 6 years).

Results

One hundred twenty-nine protei

SUBMITTER: Konijnenberg E 

PROVIDER: S-EPMC7254647 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature