Deficits in coordinated neuronal activity and network topology are striatal hallmarks in Huntington's disease.

ABSTRACT:

Background

Network alterations underlying neurodegenerative diseases often precede symptoms and functional deficits. Thus, their early identification is central for improved prognosis. In Huntington's disease (HD), the cortico-striatal networks, involved in motor function processing, are the most compromised neural substrate. However, whether the network alterations are intrinsic of the striatum or the cortex is not fully understood.

Results

In order to identify early HD neural deficits, we characterized neuronal ensemble calcium activity and network topology of HD striatal and cortical cultures. We used large-scale calcium imaging combined with activity-based network inference analysis. We extracted collective activity events and inferred the topology of the neuronal networ

SUBMITTER: Fernandez-Garcia S 

PROVIDER: S-EPMC7254676 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature