Different effects of SGLT2 inhibitors according to the presence and types of heart failure in type 2 diabetic patients.

ABSTRACT: BACKGROUND:The effects of sodium-glucose cotransporter 2 inhibitor (SGLT2i) on cardiac function are not fully understood. We investigated the changes in cardiac function in diabetic patients according to the presence and types of heart failure (HF). METHODS:We retrospectively identified 202 diabetic patients who underwent echocardiography before, and 6 to 24 months after the initiation of SGLT2i. After propensity score matching with diabetic patients without SGLT2i, the study population (n = 304) were categorized into group 1 (without HF nor SGLT2i; n = 76), group 2 (without HF and received SGLT2i; n = 78), group 3 (with HF but without SGLT2i; n = 76), and group 4 (with HF and received SGLT2i; n = 74). Changes in echocardiographic parameters were compared between these 4 groups, and betwee

SUBMITTER: Hwang IC 

PROVIDER: S-EPMC7254690 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature