Clinicopathologic features of infection-related glomerulonephritis with IgA deposits: a French Nationwide study.

ABSTRACT:

Background

Infection-related glomerulonephritis with IgA deposits (IRGN-IgA) is a rare disease but it is increasingly reported in the literature. Data regarding epidemiology and outcome are lacking, especially in Europe. We aimed to assess the clinical, pathologic and outcome data of IRGN-IgA.

Methods

Clinical and outcome data from patients from 11 French centers over the 2007-2017 period were collected retrospectively. We reviewed pathologic patterns and immunofluorescence of renal biopsies and evaluated C4d expression in IRGN-IgA. We analyzed the correlation between histological presentation and outcome.

Results

Twenty-seven patients (23 men, mean age: 62 ± 15 years) were included. Twenty-one (78%) had Staphylococcus aureus infection and twelve (44%) were diabetic.

SUBMITTER: Miquelestorena-Standley E 

PROVIDER: S-EPMC7254713 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature