Expression of FAM83H and ZNF16 are associated with shorter survival of patients with gallbladder carcinoma.

ABSTRACT:

Background

Recently, FAM83H was reported to have roles in cancer progression in conjunction with oncogenic molecules such as MYC and b-catenin. Moreover, the data from the public database indicates a molecular relationship between FAM83H and zinc finger proteins, especially between FAM83H and ZNF16. However, studies on FAM83H and ZNF16 in gallbladder cancer have been limited.

Methods

This study investigated the expression of FAM83H and ZNF16 in 105 gallbladder carcinomas.

Results

In human gallbladder carcinomas, immunohistochemical expression of FAM83H was significantly associated with ZNF16 expression. In univariate analysis, nuclear and cytoplasmic expression of FAM83H or ZNF16 were significantly associated with shorter survival of gallbladder carcinoma patients. Mu

SUBMITTER: Ahn SW 

PROVIDER: S-EPMC7254718 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature