Taf14 is required for the stabilization of transcription pre-initiation complex in Saccharomyces cerevisiae.

ABSTRACT:

Background

The YEATS domain is a highly conserved protein structure that interacts with acetylated and crotonylated lysine residues in N-terminal tails of histones. The budding yeast genome encodes three YEATS domain proteins (Taf14, Yaf9, and Sas5) that are all the subunits of different complexes involved in histone acetylation, gene transcription, and chromatin remodeling. As the strains deficient in all these three genes are inviable, it has been proposed that the YEATS domain is essential in yeast. In this study we investigate in more detail the requirement of YEATS domain proteins for yeast survival and the possible roles of Taf14 YEATS domain in the regulation of gene transcription.

Results

We found that YEATS domains are not essential for the survival of Saccharomyces

SUBMITTER: Peil K 

PROVIDER: S-EPMC7254723 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature