Risk assessment of neuromuscular stimulation by energy-based transurethral resection devices: an ex vivo test standard.

ABSTRACT:

Background

During transurethral resection of bladder tumours (TURB), radio-frequency (RF) currents can lead to adverse neuromuscular stimulation (NMS). Here we present a novel ex vivo method to determine the risk of RF generators and their bipolar TURB modes to cause NMS. We aimed to develop an experimental platform for safety evaluation of new RF generators and their modes with a newly established test standard, suitable for replacement or reduction of animal testing.

Methods

We tested four contemporary RF generators with their bipolar modes for TURB in saline. A two-stage ex vivo approach was pursued: First, we recorded voltages at possible positions of the obturator nerve behind a porcine bladder wall in a TURB model using 18 RF applications per generator. Second, these v

SUBMITTER: Biber U 

PROVIDER: S-EPMC7254752 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature