The compensatory phenomenon of the functional connectome related to pathological biomarkers in individuals with subjective cognitive decline.

ABSTRACT:

Background

Subjective cognitive decline (SCD) is a preclinical stage along the Alzheimer's disease (AD) continuum. However, little is known about the aberrant patterns of connectivity and topological alterations of the brain functional connectome and their diagnostic value in SCD.

Methods

Resting-state functional magnetic resonance imaging and graph theory analyses were used to investigate the alterations of the functional connectome in 66 SCD individuals and 64 healthy controls (HC). Pearson correlation analysis was computed to assess the relationships among network metrics, neuropsychological performance and pathological biomarkers. Finally, we used the multiple kernel learning-support vector machine (MKL-SVM) to differentiate the SCD and HC individuals.

Results

SCD

SUBMITTER: Chen H 

PROVIDER: S-EPMC7254770 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature