A genome-wide association study finds genetic variants associated with neck or shoulder pain in UK Biobank.

ABSTRACT:

Background

Common types of musculoskeletal conditions include pain in the neck and shoulder areas. This study seeks to identify the genetic variants associated with neck or shoulder pain based on a genome-wide association approach using 203 309 subjects from the UK Biobank cohort and look for replication evidence from the Generation Scotland: Scottish Family Health Study (GS:SFHS) and TwinsUK.

Methods

A genome-wide association study was performed adjusting for age, sex, BMI and nine population principal components. Significant and independent genetic variants were then sent to GS:SFHS and TwinsUK for replication.

Results

We identified three genetic loci that were associated with neck or shoulder pain in the UK Biobank samples. The most significant locus was in an inte

SUBMITTER: Meng W 

PROVIDER: S-EPMC7254846 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature