Macrophages enhance 3D invasion in a breast cancer cell line by induction of tumor cell tunneling nanotubes.

ABSTRACT:

Background

Metastasis is the cause of most cancer-related deaths. It is known that breast cancer cells in proximity to macrophages become more invasive in an Epidermal Growth Factor (EGF) dependent manner. Tunneling nanotubes (TNTs) are thin, F-actin containing, cellular protrusions that mediate intercellular communication and have been identified in many tumors. The mechanism of TNT formation varies between different cell types. M-Sec (TNFAIP2) has been demonstrated to be involved in TNT formation in some cell types including macrophages. Yet, the requirement of M-Sec in tumor cell TNT formation in response to macrophages has not been explored.

Aim

The aim of this study was to determine whether EGF was required for macrophage induced tumor cell TNTs in an M-Sec dependent ma

SUBMITTER: Carter KP 

PROVIDER: S-EPMC7254960 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature