STIM1 is a metabolic checkpoint regulating the invasion and metastasis of hepatocellular carcinoma.

ABSTRACT: Background: Cancer cells undergoing invasion and metastasis possess a phenotype with attenuated glycolysis, but enhanced fatty acid oxidation (FAO). Calcium (Ca²⁺)-mediated signaling pathways are implicated in tumor metastasis and metabolism regulation. Stromal-interaction molecule 1 (STIM1) triggered store-operated Ca²⁺ entry (SOCE) is the major route of Ca²⁺ influx for non-excitable cells including hepatocellular carcinoma (HCC) cells. However, whether and how STIM1 regulates the invasion and metastasis of HCC via metabolic reprogramming is unclear. Methods: The expressions of STIM1 and Snail1 in the HCC tissues and cells were measured by immunohistochemistry, Western-blotting and quantitative PCR. STIM1 knockout-HCC cells were genera

SUBMITTER: Zhao H 

PROVIDER: S-EPMC7255033 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature