Advanced biomimetic nanoreactor for specifically killing tumor cells through multi-enzyme cascade.

ABSTRACT: Although the enzyme catalytic nanoreactors reported so far have achieved excellent therapeutic efficacy, how to accurately exert enzyme activity in the tumor microenvironment to specifically kill tumor cells and avoid systemic oxidative damage would be an inevitable challenge for catalytic nanomedicine. At the present study, we fabricate an advanced biomimetic nanoreactor, SOD-Fe⁰@Lapa-ZRF for tumor multi-enzyme cascade delivery that combined specifically killing tumor cells and protect cells from oxidative stress. Methods: We first synthesized the FeNP-embedded SOD (SOD-Fe⁰) by reduction reaction using sodium borohydride. Next, SOD-Fe⁰ and Lapa cargo were encapsulated in ZIF-8 by self-assembly. In order to protect the cargo enzyme from digestion by

SUBMITTER: Liu W 

PROVIDER: S-EPMC7255035 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature