Prognostic gene expression signature revealed the involvement of mutational pathways in cancer genome.

ABSTRACT: Background: Over the years, many efforts have been made to use the gene expression profiles of cancer types/subtypes to identify the prognostic genes with their potential clinical applications. However, one major challenge remains is to predict the common prognostic genes using simultaneously the dataset of multiple cancers, especially by considering the differences in survival, expression and the associated mutated pathways. Methods: Herein, we carried out a comprehensive examination for the prognostic genes and linked them to the mutational status of 29 cancers, so as to find independent prognostic genes and mechanisms. Additionally, their diagnostic value of them was also assessed. Results: our extensive analysis revealed: 1) the number of prognostic and diagnostic

SUBMITTER: Liu H 

PROVIDER: S-EPMC7255374 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature