Mitigation of peri-implantitis by rational design of bifunctional peptides with antimicrobial properties.

ABSTRACT: The integration of molecular and cell biology with materials science has led to strategies to improve the interface between dental implants with the surrounding soft and hard tissues in order to replace missing teeth and restore mastication. More than 3 million implants have been placed in the US alone and this number is rising by 500,000/year. Peri-implantitis, an inflammatory response to oral pathogens growing on the implant surface threatens to reduce service life leading to eventual implant failure, and such an outcome will have adverse impact on public health and create significant health care costs. Here we report a predictive approach to peptide design, which enabled us to engineer a bifunctional peptide to combat bacterial colonization and biofilm formation, reducing the adverse ho

SUBMITTER: Wisdom EC 

PROVIDER: S-EPMC7255409 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature