Pumilio response and AU-rich elements drive rapid decay of Pnrc2-regulated cyclic gene transcripts.

ABSTRACT: Vertebrate segmentation is regulated by the segmentation clock, a biological oscillator that controls periodic formation of somites, or embryonic segments, which give rise to many mesodermal tissue types. This molecular oscillator generates cyclic gene expression with the same periodicity as somite formation in the presomitic mesoderm (PSM), an area of mesenchymal cells that give rise to mature somites. Molecular components of the clock include the Hes/her family of genes that encode transcriptional repressors, but additional genes cycle. Cyclic gene transcripts are cleared rapidly, and clearance depends upon the pnrc2 (proline-rich nuclear receptor co-activator 2) gene that encodes an mRNA decay adaptor. Previously, we showed that the her1 3'UTR confers instability to otherwise stable tra

SUBMITTER: Tietz KT 

PROVIDER: S-EPMC7255434 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature