MiR‑199a decreases Neuritin expression involved in the development of Alzheimer's disease in APP/PS1 mice.

ABSTRACT: Neuritin plays an important role in neural development and plasticity. A recent study demonstrated that increasing Neuritin levels attenuated synaptic damage in mice with Alzheimer's disease (AD), which exhibit a decreased Neuritin expression. However, it remains unclear as to whether Neuritin expression is regulated by microRNAs (miRNAs or miRs) in AD. In the present study, it was found that miR‑199a decreased Neuritin expression and was therefore involved in the development of AD. Subsequently, differentially expressed miRNAs in AD from datasets and the literature were recruited, and those that could bind Neuritin were predicted using bioinformatics analysis. The present study then focused on the candidate miRNAs that were highly associated with Neuritin and were upregulated in AD. The e

SUBMITTER: Song D 

PROVIDER: S-EPMC7255456 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature