Genome‑wide DNA methylation regulation analysis of long non‑coding RNAs in glioblastoma.

ABSTRACT: Glioblastoma (GBM) is a malignant brain tumor associated with high mortality. Long non‑coding RNAs (lncRNAs) are increasingly being recognized as its modulators. However, it remains mostly unexplored how lncRNAs are mediated by DNA methylation in GBM. The present study integrated multi‑omics data to analyze the epigenetic dysregulation of lncRNAs in GBM. Widely aberrant methylation in the lncRNA promoters was observed, and the lncRNA promoters exhibited a more hypomethylated pattern in GBM. By combining transcriptional datasets, it was possible identify the lncRNAs whose transcriptional changes might be associated with the aberrant promoter methylation. Then, a methylation‑mediated lncRNA regulatory network and functional enrichment analysis of aberrantly methylated lncRNAs showed that lnc

SUBMITTER: Ji J 

PROVIDER: S-EPMC7255472 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature