A risk score system based on DNA methylation levels and a nomogram survival model for lung squamous cell carcinoma.

ABSTRACT: Lung squamous cell carcinoma (LSCC) is one of the primary types of non‑small cell lung carcinoma, and patients with recurrent LSCC usually have a poor prognosis. The present study was conducted to build a risk score (RS) system for LSCC. Methylation data on LSCC (training set) and on head and neck squamous cell carcinoma (validation set 2) were obtained from The Cancer Genome Atlas database, and GSE39279 (validation set 1) was retrieved from the Gene Expression Omnibus database. Differentially methylated protein‑coding genes (DMGs)/long non‑coding RNAs (DM‑lncRNAs) between recurrence‑associated samples and nonrecurrence samples were screened out using the limma package, and their correlation analysis was conducted using the cor.test() function. Following identification of the optimal combi

SUBMITTER: Zhang M 

PROVIDER: S-EPMC7255475 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature