Upregulation of HLA-Class I and II in Placentas Diagnosed with Villitis of Unknown Etiology.

ABSTRACT: The placenta utilizes many mechanisms to protect the haploidentical fetus from recognition by the maternal immune system. However, in cases of villitis of unknown etiology (VUE), maternal lymphocytes gain access into the placenta, causing significant health risks for the fetus. Evidence suggests that VUE is a rejection response between the mother and the haploidentical fetus. Therefore, we profiled human leukocyte antigen (HLA), an important predictor of transplant rejection, in VUE using placental tissue from ten patients with VUE and ten gestational age matched controls. Placentas were stained using novel multiplexed immunofluorescence (MxIF) to investigate morphology and HLA classes I and II. Gene expression was evaluated by microarray, and where available, tissue typing of mother/baby

SUBMITTER: Enninga EAL 

PROVIDER: S-EPMC7255550 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature